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NCI Genomic Data Commons (GDC) API
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NCI Genomic Data Commons (GDC) API

The GDC Application Programming Interface (API) provides developers with a programmatic interface to query, analyze, and download GDC data and submit data to the GDC. The GDC API drives the GDC Data Portal, the GDC Submission Portal and is made accessible to external users for programmatic access to the same functionality found through GDC Portals

Data & AnalyticsHealth Life ScienceMedical RecordsScience Health PublicGenomic Variant DataGenomic Data SchemaGenomic Data Catalog
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Quicksearch Across All Resources

Perform a quick search across projects, cases, files, genes, mutations, and annotations using a simple query string.

HealthGenomicsCancerSample: query
1 credit / call
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Mutated Cases Count by Project

Returns counts for the number of cases that have associated SSM data in each project.; Produces counts for the number of cases that have associated ssm data in each project.

Health & Life ScienceGenomic Data CatalogScience, Health & Public DataSample: size, pretty
1 credit / call
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Top Cases Counts by Genes

Returns the number of cases with a mutation in each gene listed in the gene_ids parameter for each project.; Gives the number of cases with a mutation in each gene listed in the gene_ids parameter for each project. Cannot be used with format or fields parameters.

Health & Life ScienceGenomic Variant DataScience, Health & Public DataSample: gene_ids
1 credit / call
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Top Mutated Cases by Gene

Generates information about the cases that are most affected by mutations in a given number of genes.; Generates information about the cases most affected by mutations in a given number of genes, limited by size parameter.

Health & Life ScienceGenomic Variant DataScience, Health & Public DataSample: filters
1 credit / call
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Top Mutated Genes by Project

Outputs the genes that are mutated in the most cases in a specified project, counting mutations with HIGH or MODERATE impact on gene function.

Health & Life ScienceGenomic Variant DataScience, Health & Public DataSample: filters
1 credit / call
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Search Annotations

Search annotations added to data after curation

Search ApiSample: from, size, format
1 credit / call
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List annotations

Search and retrieve annotations to GDC data.

BioinformaticsGenomicsData Retrieval
1 credit / call
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Search Cases with Filters

Search and retrieve cases using the filters parameter for complex queries in JSON format.

HealthGenomicsCancerSample: size, filters
1 credit / call
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Search Cases

Search and retrieve case metadata, including nested biospecimen entities.; Search for cancer cases using complex filters, facets, and other query parameters.

MetadataQueryHealthcareSample: size, fields, filters
1 credit / call
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Query cases

Search and retrieve information related to cases, or sample donors

HealthcareCancerGenomics
1 credit / call
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Search Cases (POST)

Search and retrieve information related to cases (sample donors) in the GDC.; Search for cancer cases using POST request with JSON body containing filters and other parameters.

HealthcareGenomicsCancer Research
1 credit / call
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List CNV Occurrences by IDs

Retrieve nodes that contain the queried CNV occurrence ID using query parameter.

Health & Life ScienceGenomic Variant DataScience, Health & Public DataSample: query
1 credit / call
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List Copy Number Variation Occurrences

Allows users to access CNV entities as applied to a single case.; Lists copy number variation occurrences with filters, fields, and format options.

Sample: fields, format, filters
1 credit / call
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List CNVs by IDs

Retrieve nodes that contain the queried CNV ID using query parameter.

Health & Life ScienceGenomic Variant DataScience, Health & Public DataSample: query
1 credit / call
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List Copy Number Variations

Allows users to access data about copy number variations (CNVs).; Lists copy number variations (CNVs) with filters, pagination, sorting, and format options.

Health & Life ScienceGenomic Variant DataScience, Health & Public DataSample: size, sort, format
1 credit / call
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Download Multiple Data Files

Download multiple GDC files by providing a list of UUIDs.

DownloadFileCancerSample: ids
1 credit / call
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Search Files

Searches and retrieves files matching the specified filters using POST request. Recommended for large queries to avoid URL length limits. Example queries Gene Expression Quantification files for specific TCGA cases.

HealthGenomicsDataSample: size, format, pretty
1 credit / call
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List GDC Files with Query Parameters

Retrieve file information from the GDC using HTTP GET with query parameters for filtering and formatting.; Search and retrieve information relating to files stored in the GDC.; Retrieve a paginated list of genomic data files with optional filtering, field selection, and formatting.

MetadataQueryHealthcareSample: size, fields, format
1 credit / call
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List files

Search and retrieve information about files stored in the GDC.; Retrieve metadata for files using POST request with filters, fields, format and size parameters.

BioinformaticsGenomicsData Retrieval
1 credit / call
Unknown
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Query Files

Retrieve metadata for files from the GDC database using complex filters, with fields, format, and size parameters.

MetadataQueryHealthcareSample: size, fields, format
1 credit / call
Unknown
Latency unavailable